Hormone therapy interventions to improve the mental health and quality of life in transgender people with gender dysphoria have not been evaluated in controlled trials. Low quality evidence suggests that hormone therapy may lead to improvements in psychological functioning. Prospective controlled trials are needed to investigate the effects of hormone therapy on the mental health of transgender people.

There is no association between COVID-19 vaccination and fertility. However, male infection is associated with a short-term decline in fertility.

There were three instances of uterine hyperstimulation/ hypertonus following placement of the 3-mg PGE2 suppository, suggesting that perhaps a lower dose of PGE2 would improve its safety as a ripening agent without affecting its efficacy.

HAND2 promoter loops to an enhancer containing SNPs implicated in birth weight and gestation length regulation. Collectively, these data connect HAND2 expression at the maternal-fetal interface with evolution of implantation and gestational regulation, and preterm birth.

Among Swedish girls and women 10 to 30 years old, quadrivalent HPV vaccination was associated with a substantially reduced risk of invasive cervical cancer at the population level.

Induction of labor at 39 weeks in low-risk nulliparous women did not result in a significantly lower frequency of a composite adverse perinatal outcome, but it did result in a significantly lower frequency of cesarean delivery.

In this non-inferiority trial, the levonorgestrel IUD was non-inferior to the copper IUD for emergency contraception.

Neonatal COVID‐19 infection is uncommon, rarely symptomatic, and the rate of infection is no greater when the baby is born vaginally, breastfed or remains with the mother.

There is no significant homology or cross reactivity between the SARS-CoV-2 spike protein and placental protein Syncytin-1. Moreover, no anti-Syncytin-1 antibodies were found in vaccinated patients.

The pathology abnormalities composing SARS-CoV-2 placentitis cause widespread and severe placental destruction resulting in placental malperfusion and insufficiency. In these cases, intrauterine and perinatal death likely results directly from placental insufficiency and fetal hypoxic-ischemic injury. There was no evidence that SARS-CoV-2 involvement of the fetus had a role in causing these deaths.

Preliminary data about the use of mRNA COVID-19 vaccines during pregnancy shows adverse pregnancy & neonatal outcomes are similar to adverse outcomes pre-COVID.

Landmark RCT comparing the benefits and risks of the most commonly used hormone preparation in the US.

Read the official statement and recommendation by the USPSTF!

The reduction in the risk of eclampsia following prophylaxis with magnesium sulphate was not associated with an excess of death or disability for the women after 2 years.

Check out this guide for advising medical students who are applying to ObGyn residency programs!

New generalisable estimates of the increased risks of breast cancer associated with use of different hormone replacement preparations in the UK. The levels of risks varied between types of HRT, with higher risks for combined treatments and for longer duration of use.