All individuals with a cervix who are 21-65 years old should undergo cervical cancer screening. That means no screening before age 21, even if sexually active, and start screening at age 21, even if not sexually active. Any individual who has a cervix, regardless of gender identity, should receive cervical cancer screening. Individuals who do not have a cervix, including those who have had a total hysterectomy, do not require screening.

The term “Pap smear” encompasses both cytology testing and co-testing. Cytology testing gathers cells from the cervix to look for possible malignant changes under the microscope. Co-testing is cytology & HPV testing done simultaneously. The HPV test looks for high-risk HPV strains from the cells obtained during a Pap smear.

From ages 21-29, screen every 3 years with cytology testing. Co-testing not recommended.
From ages 30-65, screen every 3 years with cytology OR every 5 years with co-testing.
Once 65 years old, stop screening if testing history is adequately negative, or if post-hysterectomy with cervix removal.